I put my current set of Road 2's on at the beginning of this season, with 35k miles on the bike. I commute 2 hours a day on a 50/50 mix of 80mph straights and 45mph twisties, 8 months of the year. Bike is a 2007 with 43k miles on it now, full set of givis, rider weighs 115 lbs, tire pressure is always up near the max.
Previous tires and their mileages:
1. Bridgestone Whatevers (stock)... 0 - 9,500 miles (did not like these tires at all)
2. Metzeler Z6... 9,500 - 24,500 miles (loved these tires)
3. Metzeler Z6 Interracts... 24,500 - 35,000 miles (not as good as the plain Z6, much easier to slip on the exact same crosswalk paint, not as good in the wet, wore quicker, noticeably worse when leaned WAY over)
4. Michelin PR2... 35,000 - 43,500 (and counting)
The PR2's are the best tires I've had, hands down. I can afford to order new tires now before I have to put it away, but there's no point, they've got another 3 or 4k in them. MUCH better in hard corners, way easier to drag pegs with these tires. They do still slip on crosswalk paint in the rain, but it's usually predictable, and nothing grips well on that sh_t. Never slid the front tire under braking, wet or dry. I cannot imagine what another set of tires could do better, to be honest. I like to try something new every time, but it will be difficult to pass up another set of these if it's still an option.