A couple of thoughts as I read the comments of others, and some things I wish I had known when I started setting my FZ6 up for touring.
Some people mention using go cruise or cramp buster, I use both together with great success. The issue with go cruise is that it is not a real cruise control, its a throttle lock, so its great for pulling your hand off and cracking knuckles or adjusting straps/zipper on your left arm, but it doesn't work well on anything other than perfectly flat roads (a rarity in much of the east coast). The cramp buster on the other hand should require no adjustment at all, it should mimic the normal movement of your wrist allowing you to relax your grip on the throttle, which greatly reduces my wrist fatigue.
As for seats, I use the stock seat, but with an AirHawk2. It took me a while to get it comfortable, but now that I have its perfect. I rode 6 hours on Friday with 2 stops, one about 15 minutes, one about an hour (visiting my Dad as I passed through his city, it was not this long by necessity). And my butt could have done about 10 hours easily. For those wondering the way I have it adjusted is as far forward as possible, in fact it is part way onto my tank, about 40% full of air, and I put my butt all the way to the back of the driver seat touching the rise to the pillion tier of the seat. Most of the air moves into the crotch and leg areas, leaving a thin cushion under the butt. It is a little odd at first, but extremely comfortable. Occasionally it shifts to one side but that is easily corrected at the next stop. And best of all the AirHawk2 is only about $80.
Ear plugs I think are a must. I have a very quiet helmet (Shoei Qwest) and I still wear ear plugs. I find myself getting worn out much quicker without them. Any rides over 20 minutes I have ear plugs in for. Personally I use Moldex 6800 ear plugs. 32dB noise reduction, comfortable and about $25 for 200 pairs on amazon.
I agree about hydration, but I LOATHE wearing a backpack while riding, even short rides. I hate the reduced range of motion and the reduced airflow to my back. So I found a tank bag that uses a hydration bladder. Mine is the Dowco Fastrax tank bag. Even with the rather basic mouthpiece you see in the picture I can still drink while riding, and I do have a chin skirt in my helmet. The bag also has a strap that folds away so I can carry it on a hike once I am off the bike.
My biggest discomforts now are stretching legs, and clutch hand (in prolonged stop and go traffic or area with red lights).
For the legs I try stretching them on the frame sliders, but I would need massive frame sliders for that to be comfortable for more than 30 seconds. I also have looked at the engine guard and also determined that it is too expensive for my blood.
For the hand, my next step is to try lubing the cable, but I don't think that is really the problem. I remember reading about someone on here fabricating a solution, but they aren't making them anymore, or maybe that was for length of the friction zone. I forget. I don't have an issue with friction zone, I just hate shifting into neutral constantly, and this clutch requires alot more pressure to hold it open than any other bike I have ridden.
Anyways, I am finding the bike quite comfortable right now. In a little over a week I will be living off her for about 6 weeks riding 5000+ miles in that time. I might even do the IBA SoreSaddle1000 at the start of the trip. I think me and my little FZ6 are finally ready for it!
It will do me for now, until I need to shift to a trike of some sort... 
